Vasper Research

Vasper is a patented health technology designed to promote systemic health gains.

Our mission is to provide non-invasive technology solutions that allow people to actively engage their body’s natural systems in achieving optimal health and wellness.

Therefore we are dedicated to developing research studies that can help us understand how Vasper works and how it can affect people of all ages, ability levels and health statuses. We are have partnered with researchers and institutions around the world to examine hypotheses and produce rigorous scientific support for our theories.

Learn about the results we’ve seen and the new directions we are taking in research below:


HORMONES

Hormones are your body’s systemic signaling molecules and are released in different areas of the body and move through the circulatory system to regulate your body’s function and behavior. Hormones affect the body in many different ways and have significant impacts on function, form, and feel.

 
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This pilot study was designed after feedback from our clients, who reported anecdotally that Vasper had a unique ability to heighten certain beneficial hormones while having the opposite response in other stress hormones. The two categories of hormones we considered were anabolic hormones and catabolic hormones, which work in opposition to each other to build and repair (anabolic) and breakdown (catabolic). Anabolic hormones include growth hormone (IGF-1 saliva marker) and testosterone, which contribute to muscle mass, energy, endurance, confidence, resilience, and sleep. Catabolic hormones include cortisol, a hormone related to stress and inflammation, and can be triggered by mental stress as well as intensive exercise.

In this Pilot Trial, Vasper investigated the hormone response from 10-20 Vasper sessions over 4-6 weeks. This trial demonstrated that Vasper was able to release the beneficial muscle-building response of growth hormone (14% increase) and testosterone (22.5% increase) while fighting against the release of cortisol, causing a 47% decrease.

And our hormone investigation didn’t stop there.

Testosterone is a key hormone that is involved in regulating muscle growth, bone density, fat metabolism, and mood in both men and women. We explored this hormone in with five Texas Rangers players in 8 Vasper sessions over 2 weeks. 80% saw an increase in free testosterone levels, with an average increase of 132% across all participants.

 
 
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But what does all this talk about hormone levels mean?

Let’s take a look at the real-life impact of changing hormone levels. Vasper worked with San Jose Sharks Strength and Conditioning Coach Mike Potenza to work with the 131st ParaRescue Squadron to assess hormone levels and performance results. ParaRescuemen are elite military operators, who specialize in medical rescue in war zones and remote areas. Due to the stress and length of their deployments, higher cortisol levels, sleep disturbances, and the resulting effects on their performance were a top concern.

In this trial, in 6 weeks ParaRescuemen increased their anabolic hormones 42% and decreased their catabolic hormones 69% compared to a group of ParaRecuemen continuing regular training.

 
 
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The difference didn’t just show in their hormones - the Vasper group performed better on typical military performance tests, such as pull-ups (2.1% increase), run time to exhaustion (17.3% improvement), and heart rate recovery (32.3% improvement).

 
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VASPER FOR CONCUSSIONS

 
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 Stable recovery after aerobic exercise with limb blood flow restriction and cooling in individuals with post-concussion syndrome

Stable recovery after aerobic exercise with limb blood flow restriction and cooling in individuals with post-concussion syndrome

 
 

The Cantu Concussion Center at Emerson Hospital is one of the leading centers of concussion clinical treatment and research. Dr. Robert Cantu with Dr. Yi-Ning Wu designed a study to examine Vasper’s potential to help with concussion treatment. They were first interested in Vasper for concussions because of the cooling and the low-impact, moderate exertion protocols that were thought to reduce the detrimental side effects that concussion patients can have. The group focused on Post-Concussive Syndrome, patients which did not have their symptoms resolve after having a concussion and are typically considered difficult cases to manage.

The midpoint results of this study on Post-Concussive Syndrome rehabilitation shows that in 6 weeks of 2x Vasper sessions/week with physical therapy, the Vasper group showed statistically significant improvements over the control group, which just did physical therapy. Not only did the Vasper group demonstrate significantly improved quality of life at the end of the study, they also showed improvements in the follow-up period, when they weren't doing Vasper or physical therapy for six weeks. The Vasper group had a significantly more stable recovery and specifically significant more stability in emotional and sleep contributions after 6 weeks of no rehabilitation. Symptom variability and stability of recovery is a particularly difficult issue in Post-Concussive Syndrome rehabilitation and this study demonstrates that Vasper is an effective way to address this.


VASPER SAFETY

Vasper puts safety first. Before starting our clinical trial in cardiopulmonary rehabilitation, cardiologist Dr. Jeff Gladden wished to determine that Vasper does not cause a response that is different than conventional exercise.

In this study, we compared heart rates and blood pressure values in 7 sessions with different leg pressures applied, ranging from 0mmHg to 85 mmHg.

 
 
 Pilot Safety Study: The Use of Vasper, A Novel Blood Flow Restriction Exercise In Healthy Adults (J Exc Phys 2016)

Pilot Safety Study: The Use of Vasper, A Novel Blood Flow Restriction Exercise In Healthy Adults (J Exc Phys 2016)

 
 

There was no significant difference in heart rate or blood pressure when comparing a session without Vasper’s cooling cuffs to a session with the cuffs at our allowed range of pressure (0-80mmHg).

The study can be read in full here in the Journal of Exercise Physiology.


VASPER AND STEM CELLS

You’ve probably heard about stem cells in many different contexts. Stem cells are used in surgery, rehabilitation, medical devices, outpatient treatments, cosmetology, and dermatology. Broadly, stem cells are cells that have more potential to change into other cell types. These cells can be used to create and regenerate tissue, the most common form of use. Due to some initial results reported by patients, Vasper started collaborating to examine the potential to increase mobilization (or activation) of stem cells.

The Andrew’s Institute is one of the foremost orthopedic surgery centers in the world. Dr. Adam Anz was interested in looking at CD34+, a marker of Hematopoietic Stem Cells (HSC). HSC are stem cells that have the potential to become all types of blood cells - red blood cells, platelets, and white blood cells. These are critical actors in the regrowth of cartilage - they help the cartilage, a living tissue, to grow where there has been a deficit.

 
 
 Environmental Mobilization of Hematopoietic Stem Cells with Exercise, Compression, and Cooling (Andrew’s Institute, FL)

Environmental Mobilization of Hematopoietic Stem Cells with Exercise, Compression, and Cooling (Andrew’s Institute, FL)

 
 

This study demonstrated that HSC can be significantly increased immediately after a Vasper session, and a significant increase of lympohocytes plus the decrease of neutrophils represents a favorable interaction of the body’s ability to prepare for resolution of muscle injury.

Jagiellonian University, a top research university in Krakow, Poland, saw the above results and thought there might be applications in cardiology. Dr. Mikolaj Maga is leading a study that looks at how your stem cells and blood vessels respond to exercise with Vasper. Just as stem cells can help regrow cartilage, they also help repair vessels and veins (the endothelium), a process called angiogenesis

The first pilot trail is focused on healthy volunteer subjects to establish basic safety and efficacy in order to continue the larger study in people with Peripheral Artery Occlusive Disease, a chronic inflammatory vascular disease. PAOD is diagnosed in 20% of Europeans and Northern Americans above 55 years old and is one of the main causes of deaths and disability in western countries. This study seeks to understand if the intervention of Vasper has the potential to increase endothelium function and angiogenesis in patients with PAOD.

 
 
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The results showed improved markers of VEGF, CD31, and CD34. This shows that the process of neoangiogenesis, or of new growth of vessels from blood stem cells, is supported by Vasper. Aspects of the arteries in the subjects improved as well - the Reflexion Index and Stiffness Index improved.

This trial on healthy subjects is now complete and Dr. Maga is continuing the investigation in the full study, Influence of physical training with vein occlusion and cooling on endothelium function and angiogenetic processes in patients with peripheral artery occlusive disease.


 

Learn MORE about vasper SCIENCE

 

Basic Science literature

Vasper’s dedication to scientific merit does not stop at our doorstep. Vasper collaborates and learns constantly from the scientific work done by others on the science of blood flow restriction, cooling, interval training, and exercise physiology. Below are some of our top resources in background scientific literature, not specific to the Vasper device, that investigate our mechanisms and drive our hypotheses for future studies.